I just recently finished my second course of Levaquin since Nov. 2013. Both courses were incorporated with Prednisone in fairly high doses. Twice I was admitted to the hospital for asthma exacerbations and this was part of my course of treatment. I didn’t notice any side effects after the first course, but after the second one, I have been experiencing extreme knee joint pain and swelling. It is difficult to walk from one to another some days. At this point I am still on prednisone to help me breathe, but I have to wonder after doing this research and reading if my joint pain isn’t a result of the Levaquin. I haven’t been back to work since this last bout of asthma and I am not sure how I am going to be able to work. I am a nurse in a busy ER. The thought of walking on these painful knees everyday makes me want to cry.